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An L18（37） orthogonal experiment was designed with seven factors and three values including blades numbers, outlet angle, outlet width, etc. 18 impellers were designed totally. The two stages of whole flow field on deep well pump in the operating point for design was simulated by using CFD. The 18 groups of the design scheme for efficiency and head were obtained. Using Latin square test, the effect of geometrical parameters on efficiency and head were researched. The primary and secondary sequence of the design parameters were acquired by the method of variance analysis. According to the test result and optimization design with experimental research, an optimum program to further design was put forward. The result could be instructive to the design of the deep well pump, which was designed by the impeller head maximum approach.